Partitron 25, a multi-purpose industrial centrifugal partition chromatograph: Rotor design and preliminary results on efficiency and stationary phase retention

摘要

A new preparative chromatograph with a capacity of 25 liters has been designed to meet the most rigorous industrial criteria. All parts contacting liquid phases are made of titanium. The rotor, cast in one piece, can be operated up to 150 bars (2,000 psi). Preliminary results on retention of the liquid stationary phases from non-aqueous and aqueous-aqueous biphasic solvent systems are presented and commented. A special emphasis is made on the theoretical plate number generated by each individual partition cell. The results highlight the benefit of a new concept of rotor featuring a better mass transfer than that observed in the stacked disk rotors. Finally, the use of neoteric solvents (ionic liquids, supercritical carbon dioxide) is mentioned.