Complexation of aminoglutethimide with native and modified cyclodextrins

摘要

Complexations of R(+) and RS(+/-)aminoglutethimide (AGT), the drug used in a treatment of breast and prostate cancer with native and modified cyclodextrins (alpha-CD, beta-CD, gamma-CD, 2,6-di-O-methyl-beta-CD (DM-beta-CD), 2,3,6-tri-O-methyl-beta-CD (TM-beta-CD) and carboxymethyl-beta-CD (CM-beta-CD)) were studied. The stability constants were determined with UV-Vis spectrophotometric method at pH 9.0. The NMR data obtained for TM-beta-CD suggest that the complexation of AGT is possible from both sides of CD molecule. This was confirmed by molecular dynamic simulations.