Anti-Nociceptive Assets of Coral Associated Gastropod,Drupa margariticola

摘要

The extract of gastropod, Drupa margariticola tested for their analgesic assets using chemical (acetic acid) induced and hot plate method on Swiss mice model showed promising results. One hundred percent column purified extracts of the D. margariticola (25 and 100 mg kg~-1p.o.) exhibited significant (p<0.00l) writhing inhibition of 65 and 78.57%, respectively against acetic acid induced abdominal constrictions. The result of hot plate study, in the difference between the mean reaction time and increased percentage of jump response of test animals in the treated groups, control and standard groups were statistically significant (p<0.00l). At 30 min, the mean reaction time for extracts (50 mg kg~-1p.o.) group was 6.67+-1 sec, when compared to control group (2.67+-0.52 sec) andpentazocine treated groups (11.5+-1.22 sec) for 100 mg kg~-1p.o.