Development of a mechanism-based pharmacokinetic/target occupancy/pharmacodynamic model to characterize the effect on neutrophil count by JNJ-61610588, an anti-VISTA monoclonal antibody, in cynomolgus monkeys

Jiang Xiling; Niu Jin; Leu Jocelyn; Singh Indrajeet; Snyder Linda A.; Sun Yu-Nien; Wang Weirong

首页> 外文期刊>Journal of pharmacokinetics and pharmacodynamics >Development of a mechanism-based pharmacokinetic/target occupancy/pharmacodynamic model to characterize the effect on neutrophil count by JNJ-61610588, an anti-VISTA monoclonal antibody, in cynomolgus monkeys

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Development of a mechanism-based pharmacokinetic/target occupancy/pharmacodynamic model to characterize the effect on neutrophil count by JNJ-61610588, an anti-VISTA monoclonal antibody, in cynomolgus monkeys

机译：建立基于机制的药代动力学/目标占有率/药效学模型以表征食蟹猴中抗VISTA单克隆抗体JNJ-61610588对嗜中性白细胞计数的影响

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来源
《Journal of pharmacokinetics and pharmacodynamics》 |2016年第suppla期|共2页
作者
Jiang Xiling; Niu Jin; Leu Jocelyn; Singh Indrajeet; Snyder Linda A.; Sun Yu-Nien; Wang Weirong;
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1. Development of a mechanism-based pharmacokinetic/target occupancy/pharmacodynamic model to characterize the effect on neutrophil count by JNJ-61610588, an anti-VISTA monoclonal antibody, in cynomolgus monkeys [J] . Jiang Xiling, Niu Jin, Leu Jocelyn, Journal of pharmacokinetics and pharmacodynamics . 2016,第Suppla期

机译：建立基于机制的药代动力学/目标占有率/药效学模型以表征食蟹猴中抗VISTA单克隆抗体JNJ-61610588对嗜中性白细胞计数的影响
2. Modeling the pharmacokinetic‐pharmacodynamic relationship of the monoclonal anti‐macaque‐IL‐15 antibody Hu714MuXHu in cynomolgus monkeys [J] . Arunan Kaliyaperumal, Babette M. Boren, Eric A. Butz, Pharmacology Research & Perspectives . 2015,第6期

机译：用Cynomolgus Monkeys中单克隆抗Macaque-IL-15抗体Hu714Muxhu的药代动力学 - 药物动力学关系
3. A Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for Bococizumab, a Humanized Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9, and Its Application in Early Clinical Development [J] . Udata Chandrasekhar, Garzone Pamela D., Gumbiner Barry, The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2017,第7期

机译：一种基于机制的药代动力学/药效学模型，用于Bococizumab，一种针对Proprotein转化酶枯草杆菌蛋白酶/ kexin型/ kexin的人源化单克隆抗体，及其在早期临床发展中的应用
4. Comprehensive mechanism-based antibody pharmacokinetic modeling [C] . Chabot Jeffrey R., Dettling Danielle E., Jasper Paul J., 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2011

机译：基于综合机理的抗体药代动力学模型
5. Mechanism-based pharmacokinetic/pharmacodynamic PK/PD modeling of corticosteroids and antiretrovirals. [D] . Fang, Jing. 2012

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6. Mechanistic Pharmacokinetic/Target Engagement/Pharmacodynamic (PK/TE/PD) Modeling in Deciphering Interplay Between a Monoclonal Antibody and Its Soluble Target in Cynomolgus Monkeys [O] . Weirong Wang, Xiaofeng Wang, Rajitha Doddareddy, 2014

机译：破译食蟹猴中单克隆抗体与其可溶性靶标之间相互作用的机械药代动力学/靶标参与/药效学（PK / TE / PD）建模
7. Mechanistic Pharmacokinetic/Target Engagement/Pharmacodynamic (PK/TE/PD) Modeling in Deciphering Interplay Between a Monoclonal Antibody and Its Soluble Target in Cynomolgus Monkeys [O] . Weirong Wang, Xiaofeng Wang, Rajitha Doddareddy, 2013

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Development of a mechanism-based pharmacokinetic/target occupancy/pharmacodynamic model to characterize the effect on neutrophil count by JNJ-61610588, an anti-VISTA monoclonal antibody, in cynomolgus monkeys

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