Effect of vehicle on drug release profiles of time-controlled release granule containing metominostrobin

摘要

We examined the effect of talc as an vehicle on release profile of time-controlled release granule (TCRG). In this report, TCRG was prepared by coating a water insoluble polymer to the pre-coated granule which consists of a powder blend containing sctive ingredient, swelling agent and talc. The lag time of metominostrobin release from TCRG was prolonged with increase of talc, a hydrophobic vehicle. We discussed the mechanism in the this phenomenon.