首页> 外文期刊>Journal of nuclear medicine technology >Pinhole versus parallel-hole collimators for parathyroid imaging: an intraindividual comparison.
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Pinhole versus parallel-hole collimators for parathyroid imaging: an intraindividual comparison.

机译:甲状旁腺成像的针孔准直仪与平行孔准直仪:个体差异比较。

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摘要

This study was undertaken to determine the effects of collimators on the accuracy of preoperative sestamibi parathyroid imaging of the neck. METHODS: Forty-nine patients with primary hyperparathyroidism underwent preoperative (99m)Tc-sestamibi parathyroid imaging. The protocol included early and late pinhole and parallel-hole imaging. One experienced nuclear physician, without knowledge of other test results or final diagnoses, interpreted studies. For both pinhole and parallel-hole images, focally increased sestamibi accumulation outside the normal tracer biodistribution that persisted or increased in intensity from early to late images was interpreted as positive for a parathyroid lesion. Final diagnoses were operatively confirmed in all patients. RESULTS: Fifty-four parathyroid lesions were resected from the 49 patients. Forty-five patients had single-gland disease. Four patients had multigland disease: 3 had 2 lesions and 1 had 3 lesions. Median lesion weight was 840 mg. Pinhole imaging was significantly more sensitive than parallel-hole imaging (89% vs. 56%; P = 0.0003) for all 54 lesions. Specificity did not significantly differ between pinhole and parallel-hole imaging (93% vs. 96%, P = 0.29). Pinhole imaging was significantly more sensitive than parallel-hole imaging for lesions above (100% vs. 68%, P = 0.003) and below (77% vs. 42%, P = 0.03) the median weight and for single-gland disease (96% vs. 67%, P = 0.001). Pinhole imaging also was more sensitive for multigland disease, although the difference was only marginally significant (55% vs. 0%, P = 0.037). CONCLUSION: Because sensitivity is significantly higher, sestamibi parathyroid imaging of the neck should be performed with a pinhole collimator.
机译:进行这项研究是为了确定准直仪对术前颈部司他他比甲状旁腺成像准确性的影响。方法:对49例原发性甲状旁腺功能亢进患者进行术前(99m)Tc-司他他比甲状旁腺显像。该协议包括早期和晚期的针孔成像和平行孔成像。一位经验丰富的核医师在不了解其他测试结果或最终诊断的情况下,对研究进行了解释。对于针孔和平行孔图像,从早期到晚期图像,正常示踪剂生物分布以外的稳定的司他他比蓄积持续存在或强度增强,这被认为是甲状旁腺病变的阳性。所有患者均经手术确认最终诊断。结果:49例患者中切除了54个甲状旁腺病变。四十五名患者患有单腺疾病。 4名患有多腺疾病的患者:3名有2个病灶,1名有3个病灶。病变中位数为840 mg。对于所有54个病变,针孔成像显着高于平行孔成像(89%比56%; P = 0.0003)。针孔和平行孔成像之间的特异性无显着差异(93%对96%,P = 0.29)。对于中位体重高于(100%vs. 68%,P = 0.003)和低于(77%vs. 42%,P = 0.03)的病变以及单腺疾病(p%)而言,针孔成像比平行孔成像更敏感。 96%和67%,P = 0.001)。针孔成像对多腺疾病也更敏感,尽管差异仅在边缘上显着(55%vs. 0%,P = 0.037)。结论:由于敏感性明显更高,因此应使用针孔准直仪对颈部的司他他比甲状旁腺进行影像学检查。

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