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首页> 外文期刊>Journal of pharmaceutical sciences. >Role of pellet size, shape, and filling method in achieving fill weight uniformity for encapsulated pelletized systems: a comparison of experiment and computer simulation.
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Role of pellet size, shape, and filling method in achieving fill weight uniformity for encapsulated pelletized systems: a comparison of experiment and computer simulation.

机译:粒料的大小,形状和填充方法在实现封装粒化系统的填充重量均匀性方面的作用:实验与计算机仿真的比较。

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摘要

Correlations between experimental filling and computer simulation for real pelletized systems were evaluated in this study. Simulations were successful in predicting the fill weight variability of a variety of pellet sizes and shapes and demonstrated similar values and trends to those observed experimentally. Simulation also helped identifying the critical variables affecting filling consistency such as pellet attributes and filling methods. Unit filling and automatic filling were found to be more comparable to simulation whilst manual flood filling appeared to lack reproducibility. Computer simulation can therefore be used as a method for predicting fill weight variability for different pellet fractions filled using different filling methods, which can facilitate process control and assurance of product quality.
机译:在这项研究中评估了真实粒状系统的实验填充与计算机模拟之间的相关性。模拟成功地预测了各种颗粒大小和形状的填充重量变异性,并证明了与实验观察到的相似的值和趋势。模拟还有助于确定影响填充一致性的关键变量,例如颗粒属性和填充方法。发现单元填充和自动填充与模拟更可比,而手动洪水填充似乎缺乏可重复性。因此,计算机仿真可以用作预测使用不同填充方法填充的不同粒料馏分的填充重量变异性的方法,这可以有助于过程控制和产品质量的保证。

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