Determination of lansoprazole in pharmaceutical capsules by flow injection analysis using UV-detection.

摘要

The direct determination of lansoprazole by using a flow injection analysis (FIA) with UV-detection and its application to the pharmaceutical capsules is described, in this study. The best carrier solvent was found to be 0.01M NaOH and it was determined at optimum conditions such as flow rate of 1mlmin(-1) and wavelength of 292nm. Examining the repeatability of the method that was found to be 1.72% for intra-day and 2.13% for inter-day precision using the [Formula: see text] M lansoprazole concentration has validated the method. The linear range of the method was [Formula: see text] to [Formula: see text] M. The limit of detection and quantification was found to be [Formula: see text] and [Formula: see text] M, respectively. The proposed method was applied to the pharmaceutical capsules and very good results obtained. Thus, the FIA method for the quantification of lansoprazole can be proposed as a cheap, rapid, easy, accurate, and precise method for the routine determination in pharmaceutical preparations.