Efficacy of a simethicone, activated charcoal and magnesium oxide combination (Carbosymag?) in functional dyspepsia: results of a general practice-based randomized trial.

摘要

A simethicone, activated charcoal and magnesium oxide combination (Carbosymag(?)) has been used for almost 20 years in functional dyspepsia, but there is limited scientific evidence of efficacy.We evaluated the efficacy of Carbosymag(?) in 18- to 49-year-old patients with functional dyspepsia.A total of 276 dyspeptic patients consulting a general practitioner and meeting the Rome III criteria were included in this prospective placebo-controlled study. Variations in overall and individual dyspeptic symptoms were evaluated after 1 month of treatment.At the end of the treatment period, overall dyspeptic symptom intensity was significantly lower in the Carbosymag(?) group (P=0.01). The intensity of post-prandial fullness, epigastric pain, epigastric burning and abdominal bloating was significantly reduced in the Carbosymag(?) group relative to the placebo group (P<0.05). The number need to treat to induce a 70-% decrease in overall dyspeptic symptoms by Carbosymag(?) was 7 (IC 95%: 4-32).A simethicone, activated charcoal and magnesium oxide combination (Carbosymag(?)) was significantly more effective than a placebo on overall symptom intensity in dyspeptic patients consulting a general practitioner.