Re: Comprehensive MRA of the lower limbs including high-resolution extended-phase infra-inguinal imaging with gadobenate dimeglumine: Initial experience with inter-individual comparison to the blood-pool contrast agent gadofosveset trisodium

摘要

I was interested to read the above article comparing "newer" standard (gadobenate) versus blood-pool contrast agents (BPCA; gadofosveset) for lower-limb magnetic resonance angiography (MRA) in a somewhat small series of 20 patients.1 If MRA is indeed the authors' standard peripheral arterial imaging method, and more numbers could have been provided, then the samples are surely somewhat inadequate, given that even a basic tool such as Altman's nomogram (before going on to more complex calculations) would suggest sample sizes of 200 for starters, in order to obtain a meaningful analysis.