Rosai-Dorfman disease presenting as multiple breast masses in an otherwise asymptomatic male patient

摘要

Rosai-Dorfman disease (also known as sinus histiocy-tosis with massive lymphadenopathy) is an uncommon, idiopathic, benign entity with a typical clinical presentation of massive painless cervical lymphadenopathy in an asymptomatic young patient. However, there is a broad spectrum of presentations ranging from asymptomatic solitary extranodal masses to widespread nodal and extranodal involvement. Breast involvement in Rosai-Dorfman disease is rare. The disease has been reported in the female breast as solitary or multiple breast masses with or without disseminated systemic disease. Two cases of Rosai-Dorfman disease involving the male breast were found upon literature review, one with purely cutaneous involvement and the second a solitary lesion involving breast parenchyma. No other case was found where the initial presentation was multiple breast masses in an otherwise healthy male patient. The present report describes the case of a 59-year-old man presenting with a palpable lump in the left breast.