The 34th European muscle conference hortobagy, hungary, 17-21 september 2005.

摘要

This brief report on the 34th European Muscle Conference is to give the reader a sense of the breadth of the interest in what we could refer to as the field of myobiology. The interested reader would find the abstracts and some full papers presented at the Meeting published in Issue 1 of Volume 26 of the Journal of Muscle Research and Cell Motility (JMRCM). There were nine sessions with 51 oral presentations interspersed with time for viewing the high quality posters. The first two sessions were devoted to the so-called auxiliary triadic proteins and to excitation contraction and excitation translation coupling. Auxiliary proteins (see B. E. Flucher et al. (2005) JMRCM 26:1-7) play a role in modulating the function of the dihydropyridine receptor as both a calcium channel and a protein making a direct contact with the ryanodine receptor. The relative role and importance of the calcium channel and the direct contact depend on the type of muscle. In addition to the well known subunits of the dihydropyridine receptor recently a number of auxill-iary proteins such as junctophilin, junctin, JP45 and others have come to light (see A. Divet et al. (2005) JMRCM 26:7-12). A tendency in current work that becomes clear from the presentations is that it is important to study auxiliary proteins and subunits in their proper environment in vitro or in experimental animals, particularly mice, with the appropriate geneknocked out.