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首页> 外文期刊>Journal of neuro-oncology. >Growth retardation and bilateral cataracts followed by anaplastic meningioma 23 years after high-dose cranial and whole-body irradiation for acute lymphoblastic leukemia: case report and review of the literature.
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Growth retardation and bilateral cataracts followed by anaplastic meningioma 23 years after high-dose cranial and whole-body irradiation for acute lymphoblastic leukemia: case report and review of the literature.

机译:大剂量颅脑和全身照射治疗急性淋巴细胞白血病后23年,发育迟缓和双侧白内障继而出现间变性变性脑膜瘤:病例报告和文献复习。

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摘要

We report a case of meningioma diagnosed 23 years after high-dose cranial and whole-body irradiation for the treatment of acute lymphocytic leukemia (ALL). Radiotherapy in this case also caused early radiation injury to the lenses and the pituitary gland, with growth retardation and mineralizing angiopathy. Radiation-induced meningiomas are more commonly malignant, more commonly multiple, and more likely to recur after resection than non-radiation-induced meningiomas. Survivors of childhood ALL treated with high-dose cranial irradiation are at risk both for early radiation injury in radiosensitive organs, such as the lens and pituitary gland, and for the later development of a radiation-induced meningioma.
机译:我们报告一例大剂量颅脑和全身照射后23年诊断为脑膜瘤的病例,用于治疗急性淋巴细胞性白血病(ALL)。在这种情况下,放射治疗还导致晶状体和垂体的早期放射损伤,并伴有生长迟缓和矿化性血管病。与非放射诱发的脑膜瘤相比,放射诱发的脑膜瘤更常见为恶性,多发且切除后复发的可能性更高。用大剂量颅脑照射治疗的儿童ALL的幸存者既有放射敏感性器官(如晶状体和垂体)的早期放射损伤的风险,也有后来放射线诱发的脑膜瘤发展的风险。

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