On the origin of the triplet puzzle of homologies in receptor heteromers: toll-like receptor triplets in different types of receptors.

摘要

Based on our theory, we have discovered main triplets of amino acid residues in the GABAB1 receptor and several other neural receptors, which seem to originate from toll-like receptors and appear also as homologies in receptor heteromers. The obtained results strengthen our hypothesis that these triplets may 'guide-and-clasp' receptor-receptor interactions.