Solubility and solution thermodynamics of cetilistat in water and (acetone, isopropyl alcohol, acetonitrile) binary solvent mixtures

摘要

This study aimed to explore the solubility and solution thermodynamics of cetilistat. Data on solid-liquid equilibrium of cetilistat are essential fora preliminary study of industrial applications. The solubility of cetilistat in binary solvent mixtures consisting of (water + acetone), (water + isopropyl alcohol), and (water + acetonitrile) was measured in the temperature range of 278.15 K-323.15 K. The modified Apelblat equation, general cosolvency model and Jouyban-Acree model were used to correlate with the solubility of cetilistat. The modified Apelblat equation provided a more accurate mathematical representation of the experimental data by comparing the models. The thermodynamic properties of the solution process, including the Gibbs free energy, enthalpy, and entropy, were calculated by the van't Hoff analysis. (C) 2016 Elsevier B.V. All rights reserved.