Frank-Starling law and mass action calcium activation of the myofibril ATPase; comment on 'de Tombe PP, Mateja RD, Tachampa K, Mou YA, Farman GP, Irving TC. Myofilament length dependent activation. J Mol Cell Cardiol 2010; 48: 851-8'.

摘要

This is a question that has puzzled scientists for nearly 100 years. Earlier studies focused on biochemical and ionic mechanisms, and more recently, considerable attention has been given to structural analyses of the sarcomere as described in the review of de Tombe et al. [1 ] and other recent reviews [2,3]. Despite this considerable effort, the question remains unanswered. I suggest that one of the major limitations in thinking about this problem is the "assumption" that most workers make (and which is repeated in the review of de Tombe et al.) that the increase in Ca~(2+) sensitivity of the ATPase or contractile response is due to increased cooperativity of Ca~(2+) binding (or resulting cross-bridges) for example [1-5].