Melanoma uptake of Tc-99m complexes containing the N-(2-diethylaminoethyl)benzamide structural element

摘要

On the basis of the avid uptake of radioiodinated benzamides, by melanoma cells, Tc-99m complexes containing the structural elements of N-(dialkylaminoalkyl)benzamide pharmacophores, have been synthesized and evaluated in vitro and in vivo for melanoma uptake. One of the complexes Tc-12 containing the ligand 4-(S-benzoyl-2-thioacetyl-glycyl-glycylamido)-N(2-diethylaminoethyl)benzam ide, (11) displayed the highest melanoma uptake. The 1-h melanoma uptake values and the corresponding blood counts indicate an interdependence of tumor uptake and bioavailability of the Tc-99m complexes. [References: 14]