Isolation and Structure of Four New Ceramides from the Starfish Luidia maculata

摘要

A new sphingosine-type ceramide LMCer-1-1 (1) and three new phytosphingosine-type ceramides,LMCer- 2-1 (2),LMCer-2-6 (3),and LMCer-2-7 (4),were isolated from the anti-hyperglycemic active ceramide molecular species LMCer-1 and LMCer-2,obtained from the less polar fraction of the chloroform-methanol extract of the whole bodies of Luidia maculata.The structures of these ceramides were determined on the basis of chemical and spectroscopic evidence as:(2S,3R,4E,2'R)-2-(2-hydroxyhexadecanoylamino)-16-methyl-4-octadecene-l,3-diol (1),(2S,3S,4R,2'R)-2-(2-hydroxyhexadecanoylamino)-16-methyl-octadecane-l,3,4-triol (2),(2S,3S,4R,2'R)-2-(2- hydroxydocosanoylamino)-hexadecane-l,3,4-triol (3),and (2S,3S,4R,2'R)-2-(2-hydroxydocosanoylamino)-14- methyl-hexadecane-l,3,4-triol (4).