Simultaneous Assessment of Vessel Size Index, Relative Blood Volume, and Vessel Permeability in a Mouse Brain Tumor Model Using a Combined Spin Echo Gradient Echo Echo-Planar Imaging Sequence and Viable Tumor Analysis

摘要

PurposeCombining multiple imaging biomarkers in one magnetic resonance imaging (MRI) session would be beneficial to gain more data pertaining to tumor vasculature under therapy. Therefore, simultaneous measurement of perfusion, permeability, and vessel size imaging (VSI) using a gradient echo spin echo (GE-SE) sequence with injection of a clinically approved gadolinium (Gd)-based contrast agent was assessed in an orthotopic glioma model.