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首页> 外文期刊>Journal of Mathematical Biology >Noisy threshold in neuronal models: connections with the noisy leaky integrate-and-fire model
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Noisy threshold in neuronal models: connections with the noisy leaky integrate-and-fire model

机译:神经元模型中的噪声阈值:与噪声泄漏集成和发射模型的连接

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摘要

Providing an analytical treatment to the stochastic feature of neurons' dynamics is one of the current biggest challenges in mathematical biology. The noisy leaky integrate-and-fire model and its associated Fokker-Planck equation are probably the most popular way to deal with neural variability. Another well-known formalism is the escape-rate model: a model giving the probability that a neuron fires at a certain time knowing the time elapsed since its last action potential. This model leads to a so-called age-structured system, a partial differential equation with non-local boundary condition famous in the field of population dynamics, where the age of a neuron is the amount of time passed by since its previous spike. In this theoretical paper, we investigate the mathematical connection between the two formalisms. We shall derive an integral transform of the solution to the age-structured model into the solution of the Fokker-Planck equation. This integral transform highlights the link between the two stochastic processes. As far as we know, an explicit mathematical correspondence between the two solutions has not been introduced until now.
机译:对神经元动力学的随机特征进行分析处理是数学生物学当前面临的最大挑战之一。嘈杂的泄漏积分和发射模型及其相关的Fokker-Planck方程可能是处理神经变异性的最流行方法。另一个著名的形式主义是逃逸率模型:该模型给出了神经元在某个特定时间触发的概率,该概率知道自上一次动作电位以来经过的时间。该模型导致一个所谓的年龄结构系统,这是一种在人口动态领域中具有非局部边界条件的偏微分方程,其中神经元的年龄是自上一次峰值以来经过的时间量。在这篇理论论文中,我们研究了两种形式主义之间的数学联系。我们将把年龄结构模型的解积分转换为Fokker-Planck方程的解。这种整体转换突出了两个随机过程之间的联系。据我们所知,两个解决方案之间直到现在还没有引入明确的数学对应关系。

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