Discrete limit and monotonicity properties of the Floquet eigenvalue in an age structured cell division cycle model

摘要

We consider a cell population described by an age-structured partial differential equation with time periodic coefficients. We assume that division only occurs within certain time intervals at a rate for cells who have reached minimal positive age (maturation). We study the asymptotic behavior of the dominant Floquet eigenvalue, or Perron-Frobenius eigenvalue, representing the growth rate, as a function of the maturation age, when the division rate tends to infinity (divisions become instantaneous). We show that the dominant Floquet eigenvalue converges to a staircase function with an infinite number of steps, determined by a discrete dynamical system. This indicates that, in the limit, the growth rate is governed by synchronization phenomena between the maturation age and the length of the time intervals in which division may occur. As an intermediate result, we give a sufficient condition which guarantees that the dominant Floquet eigenvalue is a nondecreasing function of the division rate. We also give a counter example showing that the latter monotonicity property does not hold in general.