Interview with Dr. Stephen J. McSorley and Ms. Aparna Srinivasan regarding Pivotal Advance: secondary exposure to LPS suppresses CD4+ T cells and exacerbates murine typhoid. Interview by Helene F. Rosenberg.

摘要

In this Pivotal Advance manuscript, the authors address the "paradox of Salmonella immunity and immunosuppression," a term coined to describe the observation that mitogen-unrespon-sive spleen cells were recovered from mice that had generated immunity to Salmonella . In this work, Ms. Srinivasan and Dr. McSorley use adoptive transfer technology to demonstrate that immunosuppression is also an in vivo phenomenon and is not limited to CD4+ T cells with specificity for Salmonella antigens. Specifically, the authors show that CD4+ T cells (either flagellin-specific or OVA-specific) introduced into Salmonella-infected mice and subsequently activated in vivo by co-injection of respective peptide and endotoxin have only a limited ability to respond by producing IL-2 or TNF-alpha.