SYNTHESIS OF FLUORINE-18 LABELED GLUCOSE-Lys-Arg-Gly-Asp-D-Phe AS A POTENTIAL TUMOR IMAGING AGENT

摘要

As a_v(3_3 integrin is expressed on proliferating endothelial cells as well as on tumor cells of various origin, tumor-induced angiogenesis could be blocked by antagonizing the a_vbeta_3 integrin with RGD. Therefore, a_vp_3 integrin is a target for angiogenesis imaging that might be useful in assessing tumor-induced angiogenesis and identifying tumor metastasis. To design potent radiotracer for imaging angiogenesis containing a cRGD moiety should include low hepatic uptake in vivo [1].