Homogeneous metal catalysed exchange labelling of pharmaceuticals with tritiated water

摘要

Low specific activity tritiated water in conjunction with homogeneous catalysts of rhodium, ruthenium and iridium has been extensively used by the Radiochemistry group at Schering-Plough to rapidly prepare 3H labelled compounds for preliminary drug metabolism work. Such studies are used to aid in the selection of drug candidates for further evaluation and development. Through several examples, the paper will discuss the use of homogeneous metal catalysed exchange with tritiated water to label a wide range of pharmaceutical structures.