EVALUATION OF Cu-ETS FOR USE AS A PET TRACER OF REGIONAL RENAL PERFUSION

摘要

The copper-62 complex of ethylglyoxal bis(thiosemicarbazone) (Cu-ETS, Figure 1) has potential utility as a generator-based PET radiopharmaceutical for evaluation of myocardial and renal perfusion. The Cu-ETS complex does not exhibit the strong binding to human serum albumin that is observed with the related Cu-PTSM radiopharmaceutical, making Cu-ETS more suitable as a clinical agent for perfusion measurements in high-flow tissues like the renal cortex and/or hyperemic myocardium. Like Cu-PTSM, following i.v. administration Cu-ETS rapidly clears from the blood, affording prolonged tissue retention of the Cu-radiolabel via intracellular reductive decomposition of the chelate.