Preparation and biodistribution of novel ~(99m)Tc(CO)_3-CNR complexes for myocardial imaging

摘要

We evaluated lipophilicity and biodistribution of a series of ~(99m)Tc(CO)_3-ether isonitrile complexes to determine whether different lipophilicity and structure of isonitrile ligands would improve the imaging properties of the radiopharmaceutical for the heart. Novel ~(99m)Tc(CO)_3-MIBI analogs were prepared and analyzed by radio-HPLC, and their lipophilicity was determined. These new complexes could be bi- or tri-substituted in specified pH conditions like ~(99m)Tc(CO)_3-MIBI. These new complexes exhibited low liver, lungs and blood uptake compared with [~(99m)Tc(CO)_3(MIBI)_3]~+ though their heart uptake was not so high. Among these complexes, [~(99m)Tc(CO)_3(EPI)_2(OH_2)]~+ showed higher target to non-target ratios at 5 and 30 min post-injection than that of [~(99m)Tc(CO)_3(MIBI)_3]~+.