Metal complexes of salicylhydroxamic acid (H(2)Sha), anthranilic hydroxamic acid and benzohydroxamic acid. Crystal and molecular structure of [Cu(phen)(2)(Cl)] Cl center dot H(2)Sha, a model for a peroxidase-inhibitor complex

摘要

Stability constants of iron(III), copper(II), nickel(II) and zinc(II) complexes of salicylhydroxamic acid (H(2)Sha), anthranilic hydroxamic acid (HAha) and benzohydroxamic acid (HBha) have been determined at 25.0 degrees C, I = 0.2 mol dm(-3) KCl in aqueous solution. The complex stability order, iron(III) copper(II) > nickel(II) similar to zinc(II) was observed whilst complexes of H(2)Sha were found to be more stable than those of the other two ligands. In the preparation of ternary metalion complexes of these ligands and 1,10-phenanthroline (phen) the crystalline complex [Cu(phen)(2)(Cl)] Cl . H(2)Sha was obtained and its crystal structure determined. This complex is a model for hydroxamate-peroxidase inhibitor interactions. (C) 2000 Elsevier Science Inc. All rights reserved. [References: 23]