Apolipoprotein E and low-density lipoprotein receptor gene polymorphisms in dyslipidemias-associated essential hypertension.

摘要

Hypertension has been strongly linked to a variety of lipoprotein metabolic abnormalities. Polymorphisms in the genes encoding the lipoproteins involved in metabolic abnormalities are the major target for evaluating the predisposition to the development of hypertension. In this study, two candidate genes including apolipoprotein E (ApoE) and low-density lipoprotein receptor (LDLR) were selected to examine their possible contribution to hypertension in a Chinese Han population.