PD.05. The anorexigenic peptides, neuromedin U-25 and neuromedin S, are present in the human cardiovascular system and function as potent vasoconstrictors

摘要

Neuromedin U (NMU), shown to elicit a pressor response in rats (Minamino ef ah, 1985), was paired with the 'orphan' G-protein-coupled receptors, NMUl and NMU2 (Howard et ah, 2000). This peptide has an important role in energy regulation; NMU~'~ mice developed obesity (Hanada et al, 2004) and NMU Argl65Trp variant co-segregated with childhood obesity (Hainerova et ah, 2006). Recently, neuromedin S (NMS) was paired with the same receptors and also has pressor (Mori et al., 2005) and anorexigenic actions [Ida et ah, 2005) in rats. However, little is known about direct effects of these peptides on vascular beds and on their vascular effects in humans. Using a novel RIA, NMU-25-LI was detected in human plasma, left ventricle (LV), coronary artery (CA), saphenous vein (SV) and adipose tissue.