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首页> 外文期刊>Journal of infection and chemotherapy: official journal of the Japan Society of Chemotherapy >High prevalence of erythromycin resistance and macrolide-resistance genes, mefA and ermB, in Streptococcus pneumoniae isolates from the upper respiratory tracts of children in the Sapporo district, Japan.
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High prevalence of erythromycin resistance and macrolide-resistance genes, mefA and ermB, in Streptococcus pneumoniae isolates from the upper respiratory tracts of children in the Sapporo district, Japan.

机译:在日本札幌地区儿童上呼吸道分离出的肺炎链球菌中,红霉素耐药和大环内酯耐药基因mefA和ermB的患病率很高。

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Our previous study demonstrated that the frequency of penicillin-resistant Streptococcus pneumoniae (PRSP) was lower in our district than in districts in other Japanese studies. In this study, we investigated the prevalence of erythromycin resistance. The susceptibility to erythromycin and the distribution of the macrolide-resistance genes, mefA and ermB, were examined in S. pneumoniae isolates from the upper respiratory tracts of children in four cities in the Sapporo district, Hokkaido prefecture, Japan. Of the 156 isolates, 27 (17.3%) were erythromycin-sensitive, 6 (3.9%) were erythromycin-intermediately resistant, and 123 (78.9%) were erythromycin-resistant. Fifty-nine (37.8%) had the mefA gene, 89 (57.1%) had the ermB gene, and 129 (82.7%) had the mefA and/or the ermB gene. The ermB-positive isolates tended to show high resistance to erythromycin. Erythromycin-resistant isolates and the macrolide-resistance genes were often present in infants or younger children. The frequency of erythromycin-resistant isolates in the four cities was very high, ranging from 76.3% to 83. 3%, as high as the national average. Although erythromycin-resistant isolates generally tend to show cross-resistance to penicillin, the frequency of PRSP was very low in this study, as compared with other Japanese studies. Erythromycin resistance was frequently recognized not only in PRSP but also in penicillin-sensitive S. pneumoniae (PSSP) as well. In Japan, erythromycin resistance may have already become widespread, even in local areas where penicillin resistance is not especially prevalent.
机译:我们先前的研究表明,在我们地区,耐青霉素性肺炎链球菌(PRSP)的频率低于其他日本研究中的地区。在这项研究中,我们调查了红霉素耐药的患病率。在日本北海道札幌地区四个城市的儿童上呼吸道分离株的肺炎链球菌中,检测了对红霉素的敏感性以及大环内酯类耐药基因mefA和ermB的分布。在156株菌株中,有27株(17.3%)对红霉素敏感,有6株(3.9%)对红霉素有中等抵抗力,对123株(78.9%)有对红霉素的抵抗力。有59个(37.8%)具有mefA基因,其中89个(57.1%)具有ermB基因,有129个(82.7%)具有mefA和/或ermB基因。 ermB阳性分离株倾向于表现出对红霉素的高抗性。耐红霉素的分离株和大环内酯类耐药基因通常出现在婴儿或幼儿中。在这四个城市中,耐红霉素菌株的频率很高,范围从76.3%到83. 3%,与全国平均水平一样高。尽管抗红霉素的菌株通常对青霉素具有交叉耐药性,但与其他日本研究相比,本研究中PRSP的发生率很低。不仅在PRSP中,而且在对青霉素敏感的肺炎链球菌(PSSP)中也普遍认识到红霉素耐药性。在日本,即使在青霉素耐药性不是特别普遍的地区,对红霉素的耐药性也可能已经广泛普及。

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