Efficient synthesis and spectral determination of 11-[(o-; m-; and p-substituted)-phenyl]-8-chloro-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-ones

摘要

A new synthesis to obtain eleven novel derivatives of 11-[(o-; m-; and p-substituted)-phenyl]-8-chloro-3,3-dimethyl-2,3,4,5, 10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-ones with possible pharmacological activity in the central nervous system in two efficient steps has been developed. The final products were obtained by condensation and cyclization between 3-[4-chloro-1,2-phenylenediamine]-5,5-dimethyl-2-cyclohexenone with (o-; m-; and p-substituted)benzaldehyde. The structure of all products was corroborated by ir, H-1-nmr, C-13-nmr and high resolution in ms.