Synthesis and biological activity of a novel pentacyclic heterocycle

摘要

A novel pentacyclic heterocycle has been synthesized starting from D-glucose involving two crucial conversions: the intramolecular cycloaddition of O-allyloxy furanaldoxime derived from D-glucose to furanopyran-2-isoxazoline and its diastereoselective reductive cleavage to the corresponding cis-1,3-amino alcohol. The antibacterial and antifungal activities of the synthesized heterocycle have been examined.