BACKGROUND/AIMS: Sleep dysfunction is associated with altered gastrointestinal functioning and the presence of irritable bowel syndrome (IBS). We aimed to investigate whether sleep dysfunction would influence anorectal motility in IBS patients. METHODS: A total of 16 healthy volunteers and 15 IBS patients underwent anorectal manometry. The anorectal parameters included resting and squeeze sphincter pressure, sensory thresholds in response to balloon distension, and rectoanal inhibitory reflex. Sleep dysfunction was assessed by using the Pittsburgh Sleep Quality Index (PSQI). RESULTS: IBS patients had a lower threshold volume for urge (p = 0.04) and pain (p = 0.002) as compared with the controls. IBS patients with sleep dysfunction had a significantly lower threshold volume for urge (p = 0.04) and anal sphincter pressure for maximal squeeze (p = 0.048) as compared with those without sleep dysfunction. In IBS patients, the PSQI score significantly correlated with threshold volume for first sensation (r = -0.55; p = 0.03), urge (r = -0.56; p = 0.03) and pain (r = -0.58; p = 0.03). CONCLUSIONS: IBS patients with sleep dysfunction are characterized by lower thresholds for rectal perception. Sleep disturbance might be associated with anorectal dysfunction and appears to create some degree of rectal hyperalgesia in patients with IBS.
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机译：背景/目的：睡眠功能障碍与胃肠功能改变和肠易激综合征（IBS）的存在有关。我们旨在调查睡眠功能障碍是否会影响IBS患者的肛肠蠕动。方法：共有16名健康志愿者和15名IBS患者接受了肛门直肠测压。肛肠参数包括静息和挤压括约肌压力，对球囊扩张的感觉阈值和直肠抑制性反射。使用匹兹堡睡眠质量指数（PSQI）评估睡眠功能障碍。结果：与对照组相比，IBS患者的冲动阈值量（p = 0.04）和疼痛阈值量（p = 0.002）较低。与没有睡眠功能障碍的患者相比，患有睡眠功能障碍的IBS患者的催促阈值量（p = 0.04）和最大括约肌的肛门括约肌压力（p = 0.048）明显较低。在IBS患者中，PSQI评分与首次感觉的阈值量（r = -0.55; p = 0.03），冲动（r = -0.56; p = 0.03）和疼痛（r = -0.58; p = 0.03）显着相关。结论：患有睡眠功能障碍的IBS患者的特征是直肠感觉阈值较低。睡眠障碍可能与肛门直肠功能障碍有关，并可能在IBS患者中造成一定程度的直肠痛觉过敏。
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