Promotion effects of yeast hydrolysates and a mixture of safflower seed and Gasiogapi extract on longitudinal bone, proximal epiphysis, and growth hormone in rats.

摘要

Growth effects of yeast hydrolysate (YH) and a traditional Korean herbal mixture (HM, safflower seed and Gasiogapi extract) were determined in 3-wk-old male SD rats divided into 5 groups: negative control (saline); positive control (foremilk 0.5 g/kg/day); YH (0.5 g/kg/day); HM (0.2 g/kg/day); and YH + HM (0.5 + 0.2 g/kg/day). Tibia bone length was 9.22 mm in control rats, while YH and YH + HM groups had markedly longer tibia bones than controls (9.75 and 10.46 mm, respectively). Proximal epiphyses of YH, HM and YH + HM were 0.75, 0.70 and 0.75 mm, respectively, while length in the control group was 0.50 mm. Plasma insulin growth factor-1 (IGF-1) level was slightly greater in the YH group (1.36 mg/ml) than in control rats (1.29 mg/ml). Plasma IGF-1 level was markedly increased in HM (1.49 mg/ml) and YH + HM (1.53 mg/ml) groups compared to the control (1.29 mg/ml). Growth hormone (GH) levels in YH (17.45 ng/ml), HM (15.49 ng/ml) and YH + HM (16.07 ng/ml) were markedly different compared to the control (3.63 ng/ml).