'Heparin-induced thrombocytopenia (HIT): a case study'.

摘要

The recently published article 'Heparin-Induced Thrombocytopenia (HIT): A Case Study' contains several issues that I feel need to be addressed. This article does a fine job of describing a very fulminant case of HIT where the patient died following a series of missed diagnoses as well as some questionable therapy practices. This article states in several places that the use of low molecular weight heparins (LMWH) has an effective use in anticoagulation therapy, but also states that these LMWH therapies do not need to be monitored by laboratory methods. Unfractionated heparin (UF) is commonly used in anticoagulant therapy and is monitored by a variety of methods including activated partial thromboplastin time (aPTT), anti-Xa assays, and during surgery or other invasive procedures by the activated clotting time (ACT).