Anti-leukemia activity of 7-hydroxy-2-substituted-methyl-5H-oxazolo(3,2-a)pyrimidin-5-one derivatives.

摘要

The synthesis of new 7-hydroxy-2-substituted-methyl-5H-oxazolo[3,2-a]pyrimidin-5-ones derivatives, designed as structural bicyclic analogues of the iron chelator deferiprone, is described. They were tested for their ability to inhibit proliferation in human Bcr-Abl+ leukemia cells.