Decreased repair of singlet oxygen-induced DNA damage in xeroderma pigmentosum group A cells determined by plasmid host cell reactivation

摘要

To the Editor:Xeroderma pigmentosum (XP) is a photosensitive genoderma-tosis that includes seven groups (A through G) with defective nucleotide excision repair (NER) and a variant form with defective translesional repair of ultraviolet (UV)-induced DNA damage. Patients with XP have severe sunsensitivity and a high frequency of skin cancers on sun-exposed areas. In addition, 30% of XP patients show progressive neurological degeneration [1 ]. In Japan, half of XP patients belong to XP group A (XP-A), the most severe form of neurological symptoms, however, the molecular mechanism underlying the neurological abnormalities remains unproven [1].