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首页> 外文期刊>Journal of dentistry >Comparing the efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride to a dentifrice containing 1450 ppm fluoride alone in the management of primary root caries
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Comparing the efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride to a dentifrice containing 1450 ppm fluoride alone in the management of primary root caries

机译:比较含有1.5%精氨酸和1450 ppm氟化物的洁牙剂与仅含有1450 ppm氟化物的洁牙剂在治疗原发性龋齿中的功效

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摘要

Objective: To compare the efficacy of a new dentifrice containing 1.5% arginine and 1450 ppm fluoride to a positive control dentifrice containing 1450 ppm fluoride alone in arresting and reversing primary root caries lesions in adults. Study design: A total of 3779 subjects from Piracicaba, S?o Paulo, Brazil were screened; 284 had at least one leathery primary root caries lesion and were eligible for the study. The new dentifrice contained 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride, as sodium monofluorophosphate; the matched positive control dentifrice contained 1450 ppm fluoride. One lesion for each subject was selected for inclusion in the study and was examined at baseline, 3 and 6 months. Results: A total of 253 subjects completed the study with 129 of 144 subjects included in the final statistical analysis for the test dentifrice and 124 of 140 for the positive control. The mean age of subjects was 45.7 (±9.19) years and 56.5% were female. After 6 months product use, 70.5% of root caries lesions improved for subjects using the arginine-containing dentifrice compared to 58.1% for subjects using the positive control. The difference in the number of root caries lesions becoming hard in the two groups was statistically significant (p = 0.038). Conclusion: A new dentifrice containing 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride, as sodium monofluorophosphate, provided statistically significantly superior efficacy in arresting and reversing active root caries lesions in adults compared to a matched positive control dentifrice containing fluoride alone.
机译:目的:比较含有1.5%精氨酸和1450 ppm氟化物的新型洁牙剂与仅含有1450 ppm氟化物的阳性对照洁齿剂在成年人中预防和逆转原发性龋齿的功效。研究设计:筛选了来自巴西圣保罗的皮拉西卡巴的3779名受试者; 284例患者至少有一个皮革状的原发性龋齿病灶,符合研究条件。新的洁齿剂含有1.5%的精氨酸(一种不溶的钙化合物)和1450 ppm的氟化物(单氟磷酸钠)。匹配的阳性对照洁牙剂含有1450 ppm的氟化物。为每个受试者选择一个病变以纳入研究,并在基线,3个月和6个月时进行检查。结果:总共253名受试者完成了研究,其中144名受试者中的129名受试者进行了最终洁牙剂的统计分析,而140名受试者中的124名受试者进行了阳性对照。受试者的平均年龄为45.7(±9.19)岁,女性为56.5%。在使用产品6个月后,使用含精氨酸的洁齿剂的受试者的龋齿损伤改善了70.5%,而使用阳性对照的受试者的龋齿损伤改善了58.1%。两组龋齿变硬的数量差异具有统计学意义(p = 0.038)。结论:与单独使用氟化物的匹配阳性对照洁牙剂相比,一种含有1.5%精氨酸,一种不溶性钙化合物和1450 ppm氟化物(作为一氟磷酸钠)的新洁牙剂,在阻止和逆转成人活动性根龋方面具有统计学上显着优越的功效。

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