Cosmetic liposuction causes only transient elevation of acute inflammatory response and does not advance to oxidative and nitrosative stress.

摘要

Cosmetic liposuction is a surgical procedure performed on normal nonobese subjects to remove unwanted fat. We are interested to know whether the impact of acute inflammatory response induced by liposuction differs from that of chronic inflammation and whether acute inflammatory response will also advance further and cause oxidative and nitrosative stress leading to various clinical complications. In our investigation we monitored 15 nonobese women prior to liposuction, and one day and one month after the surgery with multiple markers associated with chronic inflammation and oxidative stress. Our results indicate that liposuction causes only a transient elevation of acute inflammatory markers such as interleukin-6 (IL-6), high sensitive C-reactive protein (hCRP), and serum amyloid A (SAA), and a transient decrease of nitric oxide (NO). Apparently the impact of liposuction for normal subjects did not advance beyond acute inflammatory response; there was little change in the levels of markers corresponding to downstream events of chronic systemic inflammation such as adhesion molecules, urinary microalbumin (uMA), homocysteine (Hcy), uric acid (UA), and markers of oxidative stress, including urinary 8-hydroxydeoxyguanosine (8-OhdG) and 3-nitrotyrosine (3NT). It appears that the acute inflammatory response of cosmetic liposuction does not lead to impaired renal function and oxidative and nitrosative damage, which are frequently associated with chronic inflammation. J. Clin. Lab. Anal. 21:418-425, 2007. (c) 2007 Wiley-Liss, Inc.