Long-term results of combined transepithelial phototherapeutic keratectomy and corneal collagen crosslinking for keratoconus: Cretan protocol

摘要

Purpose To present the long-term results of combined transepithelial phototherapeutic keratectomy (PTK) and corneal collagen crosslinking (CXL) for keratoconus. Setting Vardinoyiannion Eye Institute of Crete, University of Crete, Heraklion, Crete, Greece. Design Prospective case series. Methods Patients with progressive keratoconus had combined transepithelial PTK and CXL (Cretan protocol). Visual and refractive outcomes and the endothelial cell density (ECD) were evaluated preoperatively and postoperatively. Results Twenty patients (23 eyes) were enrolled; postoperatively 23 eyes were evaluated at 1 and 2 years, 11 at 3 years, and 7 at 4 years. The mean follow-up was 33.83 months ± 10.82 (SD) (range 24 to 56 months). No intraoperative or postoperative complications occurred. The mean uncorrected distance visual acuity improved significantly from 0.99 ± 0.57 logMAR preoperatively to 0.61 ± 0.36 logMAR at the last follow-up (P <.001) and the mean corrected distance visual acuity, from 0.27 ± 0.24 logMAR to 0.17 ± 0.14 logMAR (P =.018), respectively. The mean steep and mean flat keratometry readings decreased significantly from 53.39 ± 7.14 diopters (D) and 47.17 ± 4.87 D, respectively, preoperatively to 49.99 ± 4.36 D (P <.001) and 45.47 ± 2.95 D (P =.002), respectively, at the last follow-up. The mean corneal astigmatism improved significantly from -6.27 ± 4.19 D preoperatively to -4.52 ± 2.80 D (P <.001) at the last follow-up. No significant ECD alterations occurred (P >.05). Conclusion Combined transepithelial PTK and CXL was effective and safe in keratoconic patients over a long-term follow-up. Financial Disclosure No author has a financial or proprietary interest in any material or method mentioned.