Synchronization in the Dynamics of p53 Protein Oscillations

摘要

We study the model of protein regulatory oscillator generated by p53-Mdm2feedback loop. The dynamical variables in an ensemble of such geneticallyidentical oscillators can able to show synchrony if they are coupled via variousmechanisms say direct cell contact, diffusion of signaling molecules, bindinggrowth rate influenced by other cells etc. We simulate coupled differentialequations for a group of oscillators coupled by direct coupling mechanism orMaster-slave type and the results show this correlated behavior in thedynamical variables.