Tyrosine Kinase Signaling in Clear Cell and Papillary Renal Cell Carcinoma Revealed by Mass Spectrometry-Based Phosphotyrosine Proteomics

Haake Scott M.; Li Jiannong; Bai Yun; Kinose Fumi; Fang Bin; Welsh Eric A.; Zent Roy; Dhillon Jasreman; Pow-Sang JulioM.; Chen Y. Ann; Koomen John M.; Rathmell W. Kimryn; Fishman Mayer; Haura Eric B.

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Tyrosine Kinase Signaling in Clear Cell and Papillary Renal Cell Carcinoma Revealed by Mass Spectrometry-Based Phosphotyrosine Proteomics

机译：基于质谱的磷酸酪氨酸蛋白质组学揭示透明细胞和乳头状肾细胞癌中的酪氨酸激酶信号

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Purpose: Targeted therapies in renal cell carcinoma (RCC) are limited by acquired resistance. Novel therapeutic targets are needed to combat resistance and, ideally, target the unique biology of RCC subtypes.

机译：目的：肾细胞癌（RCC）的靶向治疗受到获得性耐药的限制。需要新的治疗靶标来对抗耐药性，理想情况下，需要靶向RCC亚型的独特生物学。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2016年第22期|共12页
作者
Haake Scott M.; Li Jiannong; Bai Yun; Kinose Fumi; Fang Bin; Welsh Eric A.; Zent Roy; Dhillon Jasreman; Pow-Sang JulioM.; Chen Y. Ann; Koomen John M.; Rathmell W. Kimryn; Fishman Mayer; Haura Eric B.;
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正文语种 eng
中图分类肿瘤学;
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1. Tyrosine Kinase Signaling in Clear Cell and Papillary Renal Cell Carcinoma Revealed by Mass Spectrometry-Based Phosphotyrosine Proteomics [J] . Haake Scott M., Li Jiannong, Bai Yun, Clinical cancer research: an official journal of the American Association for Cancer Research . 2016,第22期

机译：基于质谱的磷酸酪氨酸蛋白质组学揭示透明细胞和乳头状肾细胞癌中的酪氨酸激酶信号
2. Phosphotyrosine-Based Phosphoproteomics of a Panel AML Cell Lines Reveals Oncogenic Signaling and Hyperactive Tyrosine Kinases as Targets for Treatment [J] . van Alphen Carolien, Cloos Jacqueline, Piersma Sander R., Clinical lymphoma, myeloma & leukemia . 2017,第10Suppla期

机译：面板AML细胞系的磷脂蛋白酶磷蛋白酶揭示了致癌信号和过度活性酪氨酸激酶作为治疗的靶标
3. Phosphotyrosine-Based Phosphoproteomics of a Panel AML Cell Lines Reveals Oncogenic Signaling and Hyperactive Tyrosine Kinases as Targets for Treatment [J] . Carolien van Alphen, Jacqueline Cloos, Sander R. Piersma, Clinical lymphoma, myeloma & leukemia . 2017,第10期

机译：面板AML细胞系的磷脂蛋白酶磷蛋白酶揭示了致癌信号和过度活性酪氨酸激酶作为治疗的靶标
4. Proteomics Proteomics Reveals Overexpression of the Tyrosine Kinase AXL as a Novel Mechanism of Lapatinib Resistance in Breast Tumor Cells [C] . Roland S. Annan, Therese Collingwood, Francesca Zappacosta, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：蛋白质组学蛋白质组学显示酪氨酸激酶AXL的过表达作为乳腺肿瘤细胞中Lapatinib抗性的新机制
5. c-Src tyrosine kinase regulates cell-matrix adhesion-dependent activation of Met and cell motility in breast carcinoma cells. [D] . Hui, Angela Yu-Wai. 2005

机译：c-Src酪氨酸激酶调节乳腺癌细胞中Met的细胞基质粘附依赖性激活和细胞运动。
6. Tyrosine Kinase Signaling in Clear Cell and Papillary Renal Cell Carcinoma Revealed by Mass Spectrometry-Based Phosphotyrosine Proteomics [O] . Scott M. Haake, Jiannong Li, Yun Bai, -1

机译：基于质谱的磷酸酪氨酸蛋白质组学揭示透明细胞和乳头状肾细胞癌中的酪氨酸激酶信号
7. A report of succinate dehydrogenase B deficiency associated with metastatic papillary renal cell carcinoma: successful treatment with the multi-targeted tyrosine kinase inhibitor sunitinib [O] . Tuthill, Mark, Barod, Ravi, Pyle, Linda, 2009

机译：琥珀酸脱氢酶B缺乏与转移性乳头状肾细胞癌相关的报告：用多靶点酪氨酸激酶抑制剂舒尼替尼成功治疗

Tyrosine Kinase Signaling in Clear Cell and Papillary Renal Cell Carcinoma Revealed by Mass Spectrometry-Based Phosphotyrosine Proteomics

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