From couch potato to gym junkie - CPAP may not be the answer

摘要

Obesity is a common cause of obstructive sleep apnea (OSA). Ample evidence of this is provided from longitudinal research and the OSA-minimizing effect of weight loss.1 However several lines of evidence suggest the relationship may be bi-directional and that OSA may be obesogenic. For example, OSA patients are known to have anabolic hormone deficiency,2 increased leptin resistance, and increased levels of the appetite-stimulating hormone ghrelin compared to similarly obese people without OSA.3 Patients with OSA are poorly motivated to exercise with studies, even suggesting a negative association between OSA severity and physical activity levels after adjusting for BMI.4–6 The combined effects of hormone imbalance and reduced energy expenditure would be expected to result in a positive energy balance.