Synthesis and antimicrobial activities of pyrano[3,2-c]quinoline, pyrimido [5',4':5,6]pyrano[3,2-c]quinoline and [1,2,4]triazolo[2',3':1',6']pyrimido [5',4':5,6]pyrano[3,2-c]quinoline derivatives

摘要

The synthesis of novel 7-(4-chlorophenyl)-6-hydroxy-3-methoxy-10-methyl-8, 9-dihydro-7H-pyrimido[5', 4' : 5, 6]pyrano- [3, 2-c]quinoline and [1, 2, 4]triazolo[2", 3" : 1', 6']pyrimido[5', 4' : 5, 6]pyrano[3, 2-c]quinoline derivatives has been reported. The key intermediate 2-amino-4-(4-chlorophenyl)-5-hydroxy-8-methoxy-4H-pyrano[3, 2-c]-quinoline-3-carbonitrile was obtained by treating 4-hydroxy-7-methoxyquinolin-2(1H)-one with various substituted a-cyanocinnamonitrile in ethanolic piperidine solution. Antimicrobial activity was shown for most of the synthesised compounds.