Alternative synthesis of 5-chloromethyl-2, 3-dimethoxy-6-methyl-1, 4-benzoquinone: a key intermediate for preparing coenzyme Q analogues

摘要

The title compound, a key intermediate for preparing Coenzyme Qn family, was prepared in high yield by a reaction sequence starting from the commercially available 3, 4, 5-trimethoxy-benzadehyde via Wolff-Kishner reduction, Vilsmeier-Haack reaction, Blanc chloromethylation reaction, Dakin reaction and oxidation.