Pd-catalysed ortho-C-H acylation/cross coupling of 2-arylbenzo[d]thiazoles with aldehydes using tert-butyl hydroperoxide as oxidant

摘要

An efficient palladium-catalysed protocol for direct C-H bond acylation by cross coupling of 2-arylbenzo[d]thiazoles and aldehydes using tert-butyl hydroperoxide as the oxidant is reported. The process provides a useful method for the synthesis of aromatic ketones directly from aldehydes. In addition, the reaction can tolerate various functional groups in good yield with high regioselectivity.