The development of high-throughput screening (HTS) in the past decade generated the capacity to quickly evaluate large numbers of compounds in a variety of assay methodologies. In many organizations, this capacity easily exceeded the size of internal compound collections. Efficient utilization of this HTS resource drove the need for an analogous increase in the rate of compound synthesis. This, in turn, drove the development of technologies and processes, with the goal of multiplying the capacity of classical one-at-a-time organic synthesis.
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