Solid-Supported Benzotriazoles: Synthetic Auxiliaries and Traceless Linkers for the Combinatorial Synthesis of Amine Libraries

摘要

This paper describes the successful transfer of benzotriazole-based chemistry on solid support. The strategy followed to anchor this peculiar heterocycle on solid phase and the full analytical characterization of the various supported benzotriazoles are herein described. The chemistry assessment process on solid phase, the preparation of discrete libraries by parallel synthesis, the semiautomated purification procedures, and the complete analytical characterization of the library components are also presented and discussed.