Green Chemistry Laboratory:Benign Synthesis of 4,6-Diphenyl[2,2']bipyridine via Sequential Solventless Aldol and Michael Addition Reactions

摘要

Despite the continual research surrounding pyridine molecules,the methodologies used to synthesize these compounds have changed little since Krohnke's review article in 1976(1).In general,conventional methods used in the synthesis of substituted pyridines involve volatile organic solvents(VOS)and have only moderate to low yields with low atom efficiency.The experiments herein,summarized in Scheme I,were adapted from the recent "green" literature advances in this area to fit into a 3-hour laboratory period and are part of our commitment to research and teaching in green chemistry(2).