Synthesis, crystal structures, and antibacterial activity of two hydrazone derivatives 3-methoxy-N′-(3,5-dibromo-2-hydroxybenzylidene)benzohydrazide methanol solvate and 3-methoxy-N′-(2,4-diclorobenzylidene)benzohydrazide

摘要

Two new hydrazone compounds with the formulae C_(15)H _(12)Br_2N_2O_3·CH_3OH (1) and C_(15)H_(12)Cl_2N_2O_2 (2), were prepared and characterized by elemental analysis, IR spectra and single-crystal X-ray determination. Compound (1) crystallizes in the triclinic space group P-1 with unit cell dimensions a = 7.654(1) ?, b = 13.801(2) ?, c = 16.904(2) ?, α = 90.772(2)o, β = 101.721(2)o, γ = 95.891(2)o, V = 1738.1(4) ?~3, Z = 4, R_1 = 0.0495 and wR_2 = 0.1161. Compound (2) crystallizes in the triclinic space group P-1 with unit cell dimensions a = 8.296(1) ?, b = 12.987(2) ?, c = 14.121(2) ?, α = 88.922(2)o, β = 87.960(2)o, γ = 84.130(2)o, V = 1512.3(4) ?~3, Z = 4, R_1 = 0.0526 and wR_2 = 0.1220. The single crystal structure analysis indicates that compound (1) consists of two nearly coplanar hydrazone molecules and two methanol molecules which link to the hydrazone molecules through O-H?O hydrogen bonds, while compound (2) consists of two independent distorted hydrazone molecules. In the crystal structure of (1), adjacent two hydrazone molecules are linked with methanol molecules through intermolecular hydrogen bonds of O-H?O and N-H?O, forming a dimer. In the crystal structure of (2), molecules are linked through intermolecular N-H?O hydrogen bonds, forming chains running along the a axis.